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The individual functional effect of each conservative amino acid substitution may be unnoticeable or relatively smaller than those of non-conservative substitutions, but the cumulative effects of two or more neighboring conservative substitutions at the three-dimensional space could be important for the proper protein function.
In the proposed integrative analysis, there are three distinguishing features: 1) a novel "seq2gene" strategy links genomic regions to more neighboring coding genes on both sides, 2) selective transcriptional and epigenetic data mining between cells, and 3) the prediction of "biomodules".
Varying cell cell contact resulted in a biphasic effect on proliferation; one contacting neighbor increased proliferation, while two or more neighboring cells partially inhibited this increase.
The synteny information in the clusters included (1) neighboring genes; (2) neighboring genes with a gap, which is one gene between neighbors; and (3) a genomic locus of three or more neighboring genes.
With the denser packing, each individual particle is in contact with more neighboring particles.
To accommodate all the new products the Friedmans gradually bought up more neighboring buildings.
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Specifically, we compared the expression correlation between randomly sampled mRNAs (location-independent null) to that of the following location-dependent gene pairs: (1) annotated mRNAs and their more correlated neighboring mRNA, (2) intergenic lncRNAs and their more correlated neighboring mRNA, and (3) sense-antisense partners.
It has 11 million consumers, slightly more than neighboring Hungary.
The government will also pay 2.4 million annually to the municipality and 3.6 more to neighboring communities.
For France, the primary fear, as it had been for a century or more, was neighboring Germany.
Correction, February 12 , 2016 An earlier version of this article incorrectly implied that Slovenia harbors an honor culture markedly more than neighboring countries with similar sociopolitical climates.
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CEO of Professional Science Editing for Scientists @ prosciediting.com