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However, substitution of more electronegative framework polyatoms shifted the NDR peaks to more negative voltages, corresponding to decreased reduction potentials.
As this was one of the least positive potentials at which we measured open state inactivation, we conclude that at more depolarized voltages the mutant does not exert large effects on the rate of inactivation, but this may not be true at more negative voltages.
The G-V curves for the channels mSlo1/β4, mSlo1/β4(G63A), mSlo1/β4 (H105A), mSlo1/β4(H153andand mSlo1/β4(D166R) are not statistically different from that of the wild-type (WT) mSlo1 alone channel at 10 μM Ca2+, whereas β4 mutant N123A activates the channel by significantly shifting the channel G-V curve to more negative voltages (Fig. 5a).
Studies of heterologous expression of human mutations and calcium channel functioning using whole-cell electrophysiology (for review see [40]) have shown that FHM1 mutations increase the opening probabilities of channels, also at more negative voltages, compared to what is seen in wild-type channels [41, 42].
A significant region×hemisphere interaction [F 1,60) = 14.3, p<0.01] showed more negative voltages in the left anterior region, but more negative voltages at central and posterior regions in the right hemisphere.
The effect of sex reached significance [F 1,30) = 4.8, p = 0.04], indicating more negative voltages in females as compared to male participants.
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Inspiratory-inhibited neurons exhibit significantly more positive resting membrane potential, more negative voltage threshold and lower minimal current required to evoke an action potential under current clamp.
The responsivity of the ZnO p-n diode increases when more negative voltage was applied.
However, Gate2 with more negative voltage (−0.5 V) diminishes the tunneling distance near drain side, as shown in Fig. 5c.
When the potentiostatic deposition process is used, the obtained results prove that as more negative voltage is used as bias, the electrolyte concentrations (or ion diffusion effect) will influence the compositions of the deposited (Bi,Sb 2 - xTe3 + x materials.
It is expected that voltage sensor movement has a more negative voltage-dependence than pore conductance, since activation of voltage sensors must occur before channel opening can occur [14], [23], [24], and this is observed in fluorescence reports from both Shaker [12], [13] and other Kv channels [17].
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