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Of note, both tumors harboring four or more mutations were advanced stage.
Due to MitoChip's increased sensitivity, more mutations were identified by this method than by CE DNA sequencing.
Pseudogenes with one or more mutations were identified by BLAST searches or direct analysis of all open reading frames.
Rather, longer genes simply had more mutations than smaller genes: genes with one or more mutations were significantly longer than genes without mutations (Kolmogorov Smirnov test, P < 0.001).
In families with at least one relative with ovarian cancer (P<0.0001), multiple primary breast cancers (P=0.002) or male breast cancer (P=0.002) significantly more mutations were identified compared to families without such phenotypes (Table 2).
In patients with a family history of breast/ovarian cancer, significantly more mutations were identified compared to sporadic patients (71 mutations in 291 unrelated families (24.4%) and four mutations in 58 sporadic patients (6.9%); P=0.003).
Similar(52)
More and more mutations are found that influence behaviour.
Other research has indicated that genetic vulnerability to autism differs between males and females, with more mutations being needed to produce the condition in females compared with males.
More mutations are predicted than in the core, seemingly in order to optimise the network of complementary interactions between polar and charged groups.
Undoubtedly, more mutations are to come with resounding impact on how we think, communicate and ultimately, how our governments govern.
In CMC, individuals with one or more mutations are encoded with the same genetic score.
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