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Exact(7)
It is not possible to report an overall prevalence of sequences in our dataset having one or more mutations on the list for all three drug classes because the denominators and the individuals providing sequences for the RT and protease classes were different.
In contrast, the mutator alleles produced ∼2- to 10-fold more mutations on average.
They discovered that compared to wildcats, housecats have more mutations on genes involved in mediating aggressive behavior, forming memories, and controlling the ability to learn from either fear or reward-based stimuli.
However, it is a truism that whenever a mutation regime shapes the primary structure of a DNA sequence for a long time –and the results in the previous pages leave little doubt about this being the case for NBDM in vertebrates– then a different mutation regime is likely to generate more mutations on such DNA than the actual regime which structured the DNA over the long term.
Doubling the amount of Xa mutations (n = 110) in order to correct for the single copy state of Xa still results in 3.5× more mutations on Xi.
With epistatic interactions, the combined effect of two or more mutations on fitness may be greater than, less than, or opposite in sign to expectations obtained by combining their separate effects.
Similar(53)
We cannot rule out the possibility of finding more mutation on other part of the genome.
This is not because mutations do not occur on the clonal part, but rather that they accumulate much faster on the sexual part of the genome, and hence the quadratic and truncation selection effects allow for no more mutations to accumulate on the whole genome.
Widening of the distribution is a highly undesirable effect: The wider is the distribution, the higher is the chance to arrive to potential "cancer progenitors" – cells with many more mutations than on average in a given population.
Specifically, large loci have, on average, more mutations than the small ones (three mutations in a (X 3 locus vs. seven mutations in a (X 64 locus).
In addition, we also considered the fact that gene sets with a large "set length" (defined as the total exon length of its genes) accumulate on average more mutations and for this reason show a lower variance in N/ S rates.
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