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As expected, UVB mutations were the largest single mutational class in the non-Aza BCC and one or more mutations of this type were found in 6 out of 12 (50%).
In MDS we found slightly more mutations of CBL than previously reported [ 11].
Therefore, more mutations, and especially more mutations of large effect, would be adaptive.
It will be interesting to see whether mutations affecting male-gametophyte development will be discovered by screening for more mutations of the spliceosome machinery.
Couples using ART have, in general, a higher prevalence of aberrant karyotypes than the general population, have more mutations of the CFTR gene and show more Y chromosome microdeletions (see the section 'Genetic aspects of male fertility').
That is, the increased genetic variation which is concomitant with high mutation rate may prove useful under environmental change, assuming that the greater variation affords access to more mutations of beneficial effect.
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We cannot rule out the possibility of finding more mutation on other part of the genome.
However, additional rounds of evolution, starting with variants containing fewer mutations, could stabilize the protein and allow the introduction of more mutations to further improve function.
A novel solution is offered to the old enigma of the evolution of complex features in proteins that require two or more mutations (emergence of a disulphide bond is a straightforward example).
Did it involve the rapid fixation of one or more mutations with effects of a magnitude similar to the p.D273RfsX13 MSTN mutation?
The paper's author, Peter Forster, said: "Children of 15-year-old boys have about 30% more mutations than children of young men.
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