But some of us are more mutant than others".
For example, mutations that reduce the virulence of MSV variants might, within the context of a mixed infection with wild-type highly virulent variants (i.e. situations where some degree of genetic complementation is likely), increase the replicative capacity of these mutants relative to their more virulent progenitors.
Importantly, in the small intestine, there were approximately 1.6-fold more P75+ progenitors per cross section at E18.5 in the Gas1 mutant than in the control (Fig. 5D,E, and quantification in Fig. 5F).
The repression of Ras-MAPK signaling by Cno does not account, however, for all the phenotypes detected in cno2 mutant embryos, such as cases of Eve+ progenitor losses (i.e. if Cno were merely inhibiting Ras, in cno2 mutant embryos there would be more positive Ras signaling and, thus, only more Eve+ progenitors should be found).
From E10.5 to E12.5, as more neural progenitors become fate restricted, both DNA damage and apoptosis in the Nde1 mutant cortex increased and peaked at E12.5.
Here we show that the Gas1 mutant GI tract, compared to the control, is shorter, has thinner smooth muscles, and contains more enteric progenitors that are abnormally distributed.
Each wave of erythropoiesis was reported to generate more potent progenitors (progenitors of more numerous cell types).
In an elegant study Purton et al. [ 19] have shown that loss of RARα1, but not RARα, results in reduced numbers of HSCs and increased numbers of more differentiated progenitor cells in the mutant mice.
Embryonic studies indicated that although total proliferation and radial glial cell numbers were unaffected at E14.5, there were notably more basal progenitor cells and fewer post-mitotic neurons in the mutant embryos.
The last thing I want is to know anything more about my progenitors.
