The α/β neurons might play more modulatory roles in specific visual memory tasks, such as context generalization, facilitation of operant learning and occasion setting (Liu et al., 1999; Tang and Guo, 2001; Brembs and Wiener, 2006; Brembs, 2009; Zhang et al., 2013).
It remains possible that phosphorylation of endocytic proteins may have a more minor, modulatory role in mitotic shutdown of CME, but we found no evidence that phosphorylation of the CME machinery renders it inactive.
This macrophage phenotype appears to play more of a modulatory role in wound healing, and these potential contradictory roles of macrophages may arise due to the ability of these inflammatory cells to assume a wide spectrum of functional phenotypes determined by their microenvironment [ 106].
The role of β-END in food intake regulation appears to be less prominent and more modulatory in character.
Our data based on the MCF7/IGF-1R cell model demonstrate that, more than just a modulatory role, IGF-1R conveys its own ligand receptor signaling to drive resistance to tamoxifen and FUL.
It would be interesting to perform a study on longitudinal measurements of this growth factor in normal and pathological pregnancies as results from such an observation may provide more information on its potential modulatory role in fetal growth.
Thus, while Hh signaling may influence enteric neuron pool size in vivo, this role appears more modulatory than essential.
However, there is firm evidence for more facilitating and modulatory roles of the actin filaments.
