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This clinical condition is defined as 15 or more headache days with 8 or more migraine attacks per month [3].
Non-pharmacological and pharmacological prophylaxis is required in patients with three or more migraine attacks per month [5].
Two women with more migraine attacks and without improvement in the MIDAS score, decided to change to a non-hormonal contraception after 180 days.
Patients who have an increased attention to unpleasant bodily sensations and the tendency to appraise vague somatic sensations as abnormal or pathological have more migraine attacks which may lead to a lower quality of life.
With enrollment of a larger (N = 50), more severely affected population who experienced more migraine attacks (N = 131), our research extends data from previous studies that showed a 2-h pain-free response of 22%[11]1].
We in addition to bleeding days 1 3 observed more migraine attacks at days -1and day 4. Our daily analyses of headache days over days −3 to day 5 is not comparable with the mentioned interval analyses and much more exact for the objective.
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Migraine patients with present and lifelong psychiatric diagnoses had significantly more severe headaches (p < 0.01), higher MIDAS points (p < 0.01) and more frequent migraine attacks (p < 0.05) but showed no differences based on the migraine initiation age and mean attack time (p > 0.05) compared with the migraine patients without any psychiatric diagnosis.
When a patient has two or more migraine headache attacks per month, they could benefit from preventative medications.
We also found no association for women who indicated they experienced more frequent migraine attacks.
It is reported that females have longer lasting and more severe migraine attacks than men [5, 6].
The altered neuronal excitability may cause an increased sensitivity to the CSD resulting in an increased activation of the trigeminal nociceptive fibers and consequently in more severe migraine attacks [76].
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