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In human intestine, there are 100 trillion bacteria that is ten times greater than the total number of cells in human body with at least 1,000 different species of known bacteria and carries 150 times more microbial genes than human genome (Ursell et al., 2014).
Additional grounds for targeting virulence per se is furnished by recent metagenomic studies in humans, which suggest that the human metagenome contains several orders of magnitude more microbial genes than Homo sapiens genes and that our bodies themselves contain perhaps ten times as many microbial cells as "human" ones [ 40, 41].
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One future GenoMesh research will aim to include more microbial genomes, conduct gene ortholog analysis between different microbial genomes, and evaluate the likelihood and performance of using GenoMesh to study gene-gene relations in eukaryotic systems.
With many more microbial genomes being sequenced, our results open the door to 3R gene-based studies of adaptation and evolution of other, highly clonal bacteria.
Characteristically, each MGU contains more than 700 microbial genes [ 25].
To this end, we make use of the newly available resource COMBREX [ 10], which is an online database [ 11] containing functional predictions and phenotype information for more than 3 million microbial genes (see Methods for more details).
COMBREX maintains a database [ 11] of experimentally determined and computationally predicted functions for more than 3 million microbial genes.
Plants seem to be the optimal organism in which to transplant (1) microbial genes to achieve more mineralization of organic contaminants and (2) mammalian genes that may have greater activity.
The longer read lengths have been demonstrated to yield higher detection of viral and microbial genes as well as recognition of more distal homologs [26].
Because there are so many trillions of microbes in the gut, the vast majority of the genes that a person carries around are more microbial than human.
Native Africans had more abundant butyrate producing bacteria groups with higher expression levels of microbial genes encoding for methanogenesis and hydrogen sulfide production than African Americans who were richer in expression of microbial genes encoding for secondary bile acid production.
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