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Cloning approaches and computational predictions have indicated that there are possibly even more microRNA encoding loci in the human genome [15].
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More microRNA specific normalization methods are in demand for cross-platform microRNA microarray data integration and comparison, which will improve the reproducibility and consistency between platforms.
Animals with more cell types that evolved later also evolved more microRNAs.
MicroRNAs are required for maintenance of pluripotency as well as differentiation, but since more microRNAs have been computationally predicted in genome than have been found, there are likely to be undiscovered microRNAs expressed early in stem cell differentiation.
van Rooij, E. et al. A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.
In December's Nature Genetics, he compared the microRNAs encoded by chimpanzee and human genomes.
Tang, S., Patel, A. & Krause, P. R. Novel less-abundant viral microRNAs encoded by herpes simplex virus 2 latency-associated transcript and their roles in regulating ICP34.5 and ICP0 mRNAs.
However, the functions of microRNAs encoded by PVT-1 must be taken into account.
Thus, the requirement for microRNAs encoded by the miR-17∼92 miR-17∼92s clusterntext specisicell
Furthermore, none of the pre-microRNA sequences is similar to microRNAs encoded outside the Dlk1/Gtl2 region, supporting an absence of potential paralogues in different genomic regions.
The results of our microRNA sequence analysis show that microRNAs encoded within the Dlk1/Gtl2 region are well conserved between mouse and human, both in terms of their pre-microRNA and mature sequences.
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