Sentence examples for more miRNA transcripts from inspiring English sources

More miRNA transcripts remain to be excavated extensively.

Also, in the small RNA derived sample, more miRNA transcripts were expressed above 5 tpm and in a Limma analysis comparing the small and total RNA derived Embryo samples, 6 miRNAs were shown to have significantly higher expression levels for the small RNA derived libraries (Additional file 3 Figure S2).

Compared to the previous report, apart from the reported miRNA transcripts, more miRNAs common to other organisms as well as novel miRNA transcripts were identified in this study due to the powerful coverage of the large scale sequencing capacity of Solexa technology.

This percentage continues to increase for probe-sets detecting transcripts carrying more miRNA binding sites, reaching 100% for probe-sets detecting transcripts with 4 or more binding sites.

It is probable that similar analyses performed in lines carrying mutations in genes involved in miRNA processing (in particular DCL1- plants) will allow more extensive and accurate definition of miRNA transcripts on a large scale, eventually facilitating detailed analyses of promoter sequences and a deeper understanding of mechanisms of transcriptional regulation of miRNA genes.

The explanation may be that cDNAs and ESTs represent a variety of overlapping transcribed regions, while CAGE tags near genomic locations of pre-miRNA 5'-ends more specifically pinpoints transcriptional start sites for primary miRNA transcripts.

Additionally, we observed that genes with higher transcriptional noise driven by promoter sequence content are targeted by more miRNAs compared to transcript with small noise level, suggesting the existence of coupled or coordinated mechanism for transcriptional and post transcriptional regulation.

First of all, we found that transcripts containing the novel motif have more miRNA target sites predicted in general.

Roughly half of the known human microRNAs are found in intergenic regions of the genome, suggesting production of unique primary transcripts (pri-miRNAs) containing one or more miRNA hairpins under the control of independent promoter elements.

A total of 101 unique miRNA transcripts have been detected in one or more regions of the human brain.

In order to assess the function of miRNA clusters, which are polycistronic primary miRNA transcripts that give rise to two or more mature miRNAs, we constructed two artificial miRNA cluster expression constructs (miR-15b and miR-16; miR-221 and miR-222) by sequence concatenation, as outlined in material and methods.