Importantly, TSP50+/MMP9+ tumors were associated with a significantly higher metastasis rate, as shown in Figure 7e, 70/88 (79%) breast tumor specimens were positive for both TSP50 and MMP9, and 40/70 57%) of TSP50+/MMP9+ tumors showed one or more metastatic lymph nodes, whereas other tumors showed very fewer metastatic lymph nodes.
Almost two thirds of patients had 4 or more metastatic lymph nodes at the time of diagnosis.
Postmastectomy RT is recommended to patients with 4 or more metastatic axillary nodes, gross extracapsular nodal extension, large (≥5 cm) primary tumors, and chest wall invasion.
All tumours from patients with stage IIIC were DKK1+ (P=0.04), which includes tumours of any size presenting 10 or more metastatic axillary nodes.
We performed a clinical examination of oral squamous cell carcinoma cases which received neck dissection and the results indicated that the prognoses of the cases which had three or more metastatic lymph nodes and/or extracapsular metastatic lesion were poor.
Therefore, we investigated the correlation between the expression of E-cadherin, α-catenin and β-catenin and the presence of three or more metastatic lymph nodes and/or extracapsular metastatic lesions.
Moreover, the proportion of patients with five or more metastatic lymph nodes was also significantly higher in the study group than in the control group (45% vs. 15%, P = 0.007).
Proportion of lymph node metastasis was significantly higher in study group than that in control group (90% vs. 45%, P = 0.002), and proportion of patients with 5 or more metastatic lymph nodes was also significantly higher in study group than in control group (45% vs. 15%, P = 0.007).
In this study, the proportion of lymph node metastasis was significantly higher in the GC study group than that in the control group and the proportion of patients with 5 or more metastatic lymph nodes was also significantly higher in the study group than in the control group.
