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Moreover, applied studies show that these single time series reconstructions can often be improved ad hoc by including multiple dynamically coupled time series in the reconstructions, to provide a more mechanistic model.
Finally, in a more mechanistic model of yeast cell polarization, a surface diffusion coefficient between 0.01 and 0.001 µm2/s produced the best polarization performance, and this range is close to the measured value.
A recent analysis of the application of MaxEnt to species abundance distribution argues that it is common for distributions, each resulting from one or more mechanistic model, to also be found as a solution of an appropriately formulated entropy maximization problem [34].
One might then proceed to a more mechanistic (model or hypothesis — driven) characterisation using DCM.
For comparison, HC metabolism was analyzed with a more mechanistic model that accounted for HC binding to HSA, in which only unbound HC was metabolized by hepatocytes.
The coupling of biochemical, cellular and genetic approaches has facilitated the development of a more mechanistic model for how the ethylene receptors function.
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The modeling of circulating biomarkers (see refs. 59 and 60 for reviews of modeling initiatives) is also a clear avenue in the development of more mechanistic models and for identification of predictive biomarkers.
In contrast to the two-fluid models, the discrete particle model allows the use of more mechanistic models for dispersed phase coalescence and breakup, wakes, etc., thereby allowing the dynamic prediction of flow regime evolution and transitions without the use of flow regime maps inherent in two-fluid models.
More mechanistic models that explicitly represent ROS, the damage reaction with a protein (citrate synthase) and repair reaction with a heat shock protein (Hsp90) have been presented [ 39].
The formulation of more mechanistic models, such as those already developed for prostate cancer, chronic myeloid leukemia, or high-grade glioma, including models for the analysis of full imaging data, provides an important opportunity.
In particular, in order to achieve any practical realization of individual specific, personalized therapies, it will be important to move away from strictly statistically driven models towards more mechanistic models.
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