The present approach aims to guide more mature tissue development in fibrin-based valves based on in vitro conditioning in a custom-designed bioreactor system.
The explanation is that the longer the survival time of an enterprise, the more mature the development of an enterprise and the stronger its ability to cope with its external environment.
This is demonstrated by a significant reduction in the numbers of fibres with centrally localized nuclei, as fibres with peripheral nuclei are thought to be more mature in development and therefore to have been a component of the muscle for longer (Fig. 4C).
Higher scores on the PDS represent more mature pubertal development.
Twine is much better funded and at a more mature stage of development.
In more mature stages of development and in adults, GABAA receptors acquire their classical hyperpolarizing signaling.
Interestingly, cells grown on the biomimetic substrate were more responsive to isoprenaline than those grown on the two control surfaces, suggesting topography may help induce more mature ion channel development.
As this organizational transformation evolves -- from centralized and decentralized to networked and eco-system-based -- we will also see our larger economic system also evolve from its earlier forms (state-centric, market-centric) to more mature stages of development.
