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However, this recommendation is based on preliminary data and more mature data should be available in the next year or so.
This role is carried out on an ad hoc basis and the more mature data collectors rarely call on this resource.
Although panitumumab and cetuximab were shown equally effective in patients with KRAS wild type tumours [ 26], we selected panitumumab as anti-EGFR antibody given the more mature data for panitumumb in relation to RAS mutation status.
Nonetheless, caution is recommended for extrapolation outside the context of our sample because more mature data on more recent clinical trials and future research in this topic is clearly needed.
This correlates with more mature data from colorectal cancer where the AVANT and C08 trials showed no benefit (in disease-free intervals) from the addition of adjuvant bevacizumab to patients with stage II/III colorectal cancers.
More mature data with longer follow-up time and, hence, a greater number of complete screening intervals will be required from the NHS BCSP, however, before the interval cancer rate can be fully quantified.
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Put simply (and a bit bluntly) businesses, particularly larger ones with more mature Big Data analytical operations, are finding that it is too important to be left solely in the hands of the data scientists.
More mature clinical data regarding the efficacy of IMRT in the management of H&N cancer is now emerging.
Subsequently, and with more mature survival data available, the Cochrane Collaboration [ 40] selected 12 studies [ 14- 17, 20, 21, 23, 25, 26, 37, 38, 41], including more than 18,000 women and a median follow-up of 60.4 months.
Confocal imaging confirmed different GFP intensities in nephrons at later stages: S-shaped bodies and more mature nephrons (data not shown), and we consistently found that the podocytes and their precursors at the extreme proximal end of the nephrons were almost completely devoid of β-catenin activity.
That might mean a company misses a critical opportunity for new product development or customer need that a competitor with a more mature understanding of data may capitalize upon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com