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What's more, mast cells can release inflammatory molecules called cytokines.
We have previously shown that the CF mouse has many more mast cells in the small intestine as compared to wild type (WT) mice [17].
Our previous work showed that in the small intestine of the CF mouse in comparison to WT, there are 50 100 fold more mast cells, principally in the muscularis externa [17] (Fig. 1C).
62 Combined eosinophilic/neutrophilic exacerbations show more mast cells and higher sputum ECP levels than eosinophilic exacerbations.
There were significantly more mast cells in patients with UC-only and UC-CRS compared with normal control colonic mucosa.
In women with axillary lymph node metastasis more mast cells were found in the non-involved axillary lymph nodes [ 19].
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Is it because of higher viremia in those cases, thereby triggering more mast cell activation and degranulation?
However in comparison to non depleted animals, the water injected animals had significantly more immature mast cells than mature mast cells.
More importantly, mast cells were abundantly detected with higher nuclear intensities of phospho-STAT5 staining in lesional skin of some AD patients.
Unless otherwise indicated, all the experiments carried out in the present study were conducted with 3 weeks old BMMCs, where the cell population consisted of more than 90% mast cells.
This analysis showed that genes more strongly upregulated in mast cells than predicted by differential binding of the shared factors commonly contained several binding peaks for the mast cell-specific TFs.
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