There was no family history of deafness; however, subsequent auditory assessment in the index case revealed mild left-sided presbyacusis with more marked hearing loss down to 60 dB on the right.
Mice may require more marked torsinA loss of function to fully model cholinergic vulnerability, as the heterozygous ΔE Tor1a knock-in mice retain considerable torsinA function, and do not exhibit overt abnormal movements (Tanabe et al., 2012).
This decrease was directly related to WAT mass, as previously described [ 32], but the extent of decrease was not uniform for all sites and more marked than the loss of weight.
The characteristic photoreceptor dystrophy is illustrated on the SD-OCT scan through the fovea: the parafoveal ring of slightly increased autofluorescence delineates a central area of largely preserved retinal function and anatomy from a more eccentric area with marked loss of function and outer retinal thinning.
Specifically, it was more common in the elderly, and it was associated with more marked neuronal and synaptic loss and with greater reactive gliosis.
The present study suggests that HSD is a disorder of the elderly that is associated with more marked neuronal and synaptic loss and greater reactive gliosis than that seen in HS associated with FTLD-U.
This is why you get ever-increasing drifts of vigorous daffodils, but tulips tend to increase more reluctantly and with a marked loss of vigour as it takes two or three years for most tulip bulbs to flower.
Further studies are needed to determine whether examination from one or more planes can be omitted without marked loss of sensitivity.
The mermaid phenotype in the Bmp7 Tsg double mutant results from a reduction in Bmp signaling in the ventral caudal mesoderm; this reduction is more marked than that caused by the loss of Bmp7 alone, because the single Bmp7 mutant does not exhibit a mermaid phenotype (Zakin et al., 2005).
