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Although high throughput RNAi screens for C. elegans have intrinsically high false negative rates [ 22], we reasoned that less reproducible effects were also likely to indicate RNAi clones with more marginal effects on intestinal gcs-1p::gfp.
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If this was the case, one would predict that LOX inhibition would have a more marginal effect in late-stage disease due to tumours already having significant levels of cross-linked collagen.
To summarise, Propositions 2– 6 suggest that in most cases, search costs have the more powerful marginal effect of market power, profits, consumer surplus and total welfare.
This is highly consistent with the idea that interactions may be more important that marginal effects.
Here, we were able to report specific examples of interactions explaining noticeable fractions of variation in human gene expression, with in many cases the interaction contributing more than the marginal effects to overall variance.
To be more detailed and illustrative, marginal effects (mfx) of the explanatory variable to the output variables have been made.
AMEs are useful for the interpretation of non-linear models and capture the expected change in the probability of the outcome associated with a one-unit or discrete change in a predictor variable (see Cameron & Trivedi, 2010 for more information on average marginal effects).
For proteins having stabilities close to the average observed stabilities in the simulated phylogenies (i.e., Δ G = −6.34 kcal/mol), d N/d S fluctuates between high and low values due to the more frequent mutations with marginal effects on stability (∼±1 kcal/mol).
To interpret these coefficients in a more meaningful way, we compute marginal effects in the standard way except that when calculating the average, each observation is weighted by the proportion of high-skilled women represented by the MSA-year-age group cell.
The only exception is NACT-DIST30 (habituated horizontal activity, during the last 5 minutes of the NACT test, Figure 2B), for which sex effects are more marginal (all Fs ≤ 5.1, p < 0.05).
Though western diplomats say sanctions may force Kabila and his close associates to reconsider their options, there is little sign that the pressure has had anything more than a marginal effect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com