Such endometrium and its EMs cysts may be more sensitive to carcinogenic stimulations and thus more susceptible to malignant transformation.
The link between birth weight, steroid hormones in intrauterine life such as IGF-1 and cancer risk indicates that such hormones tend to increase the number of stem cells and, by extension, more proliferating immature cells are exposed to harmful events, and consequently become more susceptible to malignant transformation (Cavalieri et al, 1997; Boyne et al, 2003).
Continuous cadmium exposure for 8 or more weeks induces malignant transformation in RWPE-1 cells, producing the tumor-forming CTPE transformant (Achanzar et al. 2001).
These findings for childhood ALL emphasize the importance of fetal growth, when lymphoid progenitor cells are not yet fully differentiated and therefore more susceptible to malignant transformation.
These findings are consistent with the evidence that childhood ALL initiation and/or promotion may begin in utero, when lymphoid progenitor cells are not yet fully differentiated and therefore more susceptible to malignant transformation.
Although HPV is transmitted sexually and infects the genitals of both sexes, the cervix remains biologically more vulnerable to malignant transformation than does the penis or anus in men.
It is tempting to speculate from this observation that cells with persistent MET activation in the context of tobacco use might be more susceptible to malignant transformation by posterior oncogenic mutations (Pleasance et al, 2009).
Moreover, it is hypothesised that a disturbance in the fetal programming of gonadal development resulting from an intrauterine hormonal imbalance may delay differentiation of germ cells and render them more susceptible to malignant transformation Rajpert-De Meytss et al, 1998).
All these data suggest a proliferation/apoptosis balance tilted to proliferation in the mammary glands of the exposed rats, and that TEB may be more susceptible to malignant transformation at 35 days of age.
