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A more malignant cell
Moreover, our IHC data showed membranous expression in human melanoma cell line 1F6, whereas the more malignant cell line Mel57 remained negative.
The difference in effects shows possible selectivity of ESE-16 toward the more malignant cell lines when compared to non-malignant cell lines.
High Fra-1 expression is associated with a more malignant cell phenotype, and suggesting that Fra-1 could have a pivotal role in breast cancer progression [ 11].
Tumor-bearing C.IL6Myc mice exhibited paraprotein 'M-spikes' upon serum protein electrophoresis, indicating either the presence of a single, greatly expanded clone of Ig-producing PCs (see, for example, the pronounced extragradient in lane 4) or the coexistence of two or more malignant cell clones prior to the emergence of the dominant clone (lanes 2, 5 and 8).
Similar(55)
Since it is difficult to obtain cultures of normal/benign human breast epithelial cells, the Huma 123 cell line is uniquely suited for comparison with more malignant cells for studies into the early stages of the development of malignancy.
All FNAB samples had 80% or more malignant cells to be included in this study.
In addition, one species, unmodified H2A 1J, displayed increased levels in the more malignant cells (Fig. 2a, b).
The larger the area and greater the depth of invasion, the more malignant cells are present and the higher the HE4 expression in corresponding tissues.
With increased time of exposure to arsenite, we found more malignant cells and greater down-expression of NKRF and up-expression of p-RelA and mot-2.
This would be expected to expose more malignant cells to the radionuclide and hence limit the local spread of the cancer.
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