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In contrast, K19 and Muc-1 are associated with more malignant breast epithelial cells [ 19].
Low energy and low total fat (polyunsaturated fatty acids in particular) intakes, and high body mass index were associated with relatively more malignant breast tumours.
We found that low intakes of energy and total fat (especially PUFA), and high BMI were associated with more malignant breast cancer.
These studies indicating an elevated level of UGT8 in more malignant breast cancer cells were performed only at the level of mRNA expression using microarray analysis and quantitative RT-PCR.
METCAM/MUC18 expression was consistently higher in cell lines established from more malignant breast carcinomas, such as SK-BR-3 and MDA-MB-468, than cell lines from less malignant breast carcinomas, such as MCF7 and MDA-MB-231.
Similar(55)
For example, promoter methylation of TWIST1, an anti-apoptotic and pro-metastatic transcription factor, is significantly more prevalent in malignant breast tissue than in healthy breast tissue [ 42], and even more prevalent in metastatic lesions relative to matched primary cancers [ 43].
CRBP-1 downregulation associates with a more malignant phenotype in breast, ovarian, and nasopharyngeal cancers.
Lung tumours are, however, morphologically more heterogeneous than malignant breast tumours, which increases the difficulties in the interpretation of the HER-2/neu staining results.
Moreover, MMP-9 was detected more frequently in malignant breast carcinoma than in benign tumour (Rha et al, 1997; Hanemaaijer et al, 2000).
For example, Cx32 expression was detected in breast cancer and significantly increased in lymph node metastases compared with primary tumors, suggesting Cx32 may be a sign of more malignant phenotype of breast cancer.
A number of prospective and retrospective studies revealed DNA aneuploid breast carcinomas as following a more malignant course than DNA diploid breast carcinomas do (Auer et al, 1980; 1984; Fallenius et al, 1988b).
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more malignant evil
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more detailed breast
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more severe breast
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more refined breast
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