A wider systems approach will be necessary to simultaneously resolve effects in relation to sex, redox status, free hemoglobin level, total hemoglobin level, and oxygen carriage, with potentially more major effects in the presence of large challenges to homeostasis such as those of malaria, diabetes, or other diseases.
This study and others that followed contributed to the overall view that miRNAs exert silencing through both mechanisms simultaneously, but the more major effect was expected at the protein level, rather than at the mRNA levels.
Therefore, the Rtm1 QTL likely harbors one or more genes with major effects in renal tumorigenesis.
Dr. Fisher puts it even more succinctly: "One of the major effects of cocaine is to make people act like dickheads".
Autism has a strong genetic basis, although the genetics of autism are complex and it is unclear whether ASD is explained more by rare mutations with major effects, or by rare multigene interactions of common genetic variants.
Many mutations affect a given phenotypic trait in much more subtle ways, and this translates the fact that the mapping of genotypic into phenotypic effects is much more complex, involving more than just a few genes with major effects.
The major effects confirmed through more traditional single gene studies include complement components C2, C4, and C1q, the HLA region, the FCGR2A and FCGR3A, PDCD1, CTLA4, interleukin-10, MBL, and PTPN22.
Four genes have very common SNPs with major effects, and carriers of more than one of these variants have a more than 50%% chance of developing AMD.
Major effects of the transgenes on plant performance are presented in more detail below and in Tables 2 and 3.
For it seems that while the more remarkable components of the gambling perestroika scheme went nowhere, some subtler aspects wrought major effects.
A small number of mutations (e.g., in Shaker, fumin, and sleepless) have major effects on sleep [ 13- 16], but many mutations have more subtle quantitative effects [ 17].
