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This new method is better than simply perform QTL mapping to hybrid performance, as we identified more loci with higher significances and more clear effects (Additional files 2, 3, and 4: Tables S1-S3).
This is distinct from other isolates in cc269 (that share five or more loci with ST-269) of which approximately 50% have IS1301 in the IGR, with a similar prevalence among carriage and disease isolates (Figure 5).
Our results indicate that the genetic architecture of miRNA expression is clearly different from mRNA expression, likely involving more loci with additive or perhaps even multiplicative effects.
In most cases, the grass carp LG showed extensive synteny towards a particular zebrafish chromosome, sharing two or more loci with zebrafish chromosome.
There appears to be significantly more loci with very high FST that are associated with RFI, yield and IMF than those with very low FST.
In summary, the simplest model for variation in germline RNAi sensitivity between N2 and CB4856 involves ppw-1, three or more loci with sensitivity-increasing effects, and five or more loci with sensitivity-decreasing effects, all of which interact non-additively.
Similar(46)
With more loci or with a higher mutation rate, the false positive rate becomes close to the nominal 5%.
GWAS of complex late-onset diseases, such as osteoarthritis and Alzheimer's disease, with sample sizes comparable to our current study (43– 45), have identified more loci compared with GWAS of longevity.
Compared to the combined GWAS (which included both males and females), the sex-stratified GWAS identified 13.6% more loci associated with the traits.
The Yoruban results, which are based on a larger sample (n = 94 individuals) with more loci (n = 31; albeit with fewer sequenced sites per locus), show a similar mean value of Tajima's D (−0.287).
Although the number of mapped peptides from the Castellana set was slightly smaller than that of the Baerenfaller set, more loci were identified with the peptides from the Castellana set.
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