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Even if mutated cancer cells do not die via this intervention, cancer still potentially becomes a more localized disease.
Therefore, blocking the influence of the cancer cells on the TME and of the TME on the cancer cells, in essence, either targeting the soil or the seed's ability to interact with it, should lead to a more localized disease and can be sufficient to kill cancer cells, either by needing a much reduced amount of additional therapy or without the need of any further radio- or chemotherapy.
This opportunistic testing has led to an increase in prostate cancer incidence, younger age at diagnosis and a shift towards more localized disease [ 5, 6].
Increased cIMT has been shown to be a marker of coexistent CVD, including cerebrovascular disease (35), and may indicate systemic atherosclerosis as well as more localized disease.
Moreno et al. found a higher rate of survival for patients who underwent endoscopic tumor surgeries, which might reflect a selection bias as this approach was more commonly used for lesser volume and more localized disease [ 19].
First, we lacked information on cancer stage at diagnosis, and treatment, which would have enabled us to examine whether improvements in survival were caused by earlier diagnosis and hence more localized disease at diagnosis or by improvements in treatments.
Similar(54)
Patients with more advanced diseases may have first entrapped more cadmium into the prostate during carcinogenesis and then excreted more cadmium into the urine during disease progression and tumor necrosis than those with more localized diseases or low-grade tumors.
The 4 main patterns of pulmonary involvement are lymphatic, diffuse alveolar septal, nodular parenchymal, and tracheobronchial, with the former 2 patterns seen more commonly in patients with systemic involvement, and the latter 2 patterns seen more commonly with localized disease.
Most μCT work has used automated thresholding techniques that normalize to bone density within the region of interest, but the density may be altered in pathologic conditions such as osteopenia, and more so with localized disease such as prostate cancer.
Prostate cancer is being detected at an earlier and more localized stage of disease with the widespread use of prostate-specific antigen (PSA) detection as well as improvement in biopsy and imaging techniques.
This is of particular importance as noninvasive active surveillance, as treatment for localized disease, becomes more widely implemented and increases in popularity as a strategy for reducing potential overtreatment [ 5].
Related(20)
more localized infection
more concentrated disease
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more identified disease
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more localized time-frequency
more active disease
more effective disease
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more localized government
more localized flooding
more complicated disease
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more dental disease
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com