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Pan et al. [31] (synthesis of 16 studies evaluating RFA versus PN) reported slightly differing pooled results with more local recurrences in case of RFA (OR, 1.81; 95% CI, 1.14 2.88; p = 0.01), but no difference in the case of distant metastases (OR, 1.63; 95% CI, 0.74 3.58; p = 0.22).
In total, 45 patients had one local recurrence, whereas 90 patients had two or more local recurrences (range 1 29).
More local recurrences were detected by nurses during on-demand follow up than during routine visits in one trial (Koinberg et al, 2004).
Ninety-eight patients (38%) had experienced one or more local recurrences prior to referral and the overall local recurrence rate was 56%.
However, after another fifteen months and two more local recurrences treated with palliative chemoradiotherapy, the patient eventually suffered diffuse systemic metastatic spread and deceased in August 2013.
Furthermore, among patients with positive margins there were more local recurrences among RIS patients compared with controls, 72% vs 33% (P=0.002).
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Although some authors report more local recurrence in patients with ILC after BCT [ 2, 73], most authors showed that there is no difference in DFS or OS after BCT in ILC versus IDC [ 74, 75].
102 In women with early small BC, electron intraoperative radiotherapy resulted in significantly more local recurrence than did conventional postoperative external radiotherapy after 5 years of follow-up, but OS did not differ between the groups.
Moreover, from a clinical perspective, a major event in MM compared to CM is also the more frequent local recurrences due to the anatomical challenges of a radical resection.
Interestingly, it was found that a cut-off level of 5 mm is decisive for the course of the disease, with significantly poorer survival rates and a trend toward more frequent local recurrence in more deeply infiltrating carcinomas.
Moreover, we found a change in the pattern of failure, with distant metastasis being more prevalent than local recurrences.
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more local Renewables
more metastatic recurrences
more local properties
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more pelvic recurrences
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more frequent recurrences
more locoregional recurrences
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