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HIF-1α and HIF-2α (collectively called the HIF-α subunits) are both expressed widely, as is HIF-1β (also called the Aryl Hydrocarbon Receptor Nuclear Translocator {ARNT}), while HIF-2β has a more limited tissue distribution.
In contrast, less severe developmental defects are observed upon targeted disruption of NFκB family members that display more limited tissue expression.
However, the more limited tissue expression of IFN-λ receptors suggests that type III IFNs do not simply recapitulate the type I IFN antiviral system.
Akt1 and Akt2 are ubiquitously expressed, whereas Akt3 has a more limited tissue distribution such as the brain, testis, lung, heart, kidney, mammary gland and fat.
In contrast, NOD2 activation only modestly reduces glucose clearance [ 104], possibly due to a more limited tissue distribution of NOD2 compared with NOD1.
IP3Rs are found at relatively low expression levels in all cell types, whereas RyRs have a more limited tissue expression and with the highest levels observed in striated muscles.
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We also confirmed tissue-specific expression of Rpl3l in another species (rat), based on a more limited set of tissue microarrays (7 tissues, with 3 replicates for each tissue).
In contrast, more limited cell and tissue types expressed PLD4, PLD5, and PLD6 transcripts.
This acellular synthetic dressing has clinical applications in full-thickness burn injury and wounds, and more limited uses in tissue regeneration.
The types of alterations would depend on the repertoire of cell-surface proteins in particular tissues and would explain the more limited range of tissues affected in SSS and the acromelic dysplasias compared with MFS.
Adult stem cells can be obtained from the human body and turned into a more limited range of tissues.
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