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This models depicts the ES cell as a highly plastic but nevertheless discrete and stable cellular entity, one that in turn gives rise through a massive switch in gene expression to discrete progenitor populations with more limited developmental potential.
Proliferation in most continuously renewing tissues is hierarchically organised, with a small number of infrequently dividing pluripotent stem cells and a larger number of rapidly dividing 'transit amplifying' cells with more limited developmental potential [ 1].
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In our developmental work with patients who have severe impingement, this was very evident as task 2 was grossly limited and more limited than other tasks.
Another permutation for future investigation may be the use of highly specific promoters to drive expression of the amiRNA, to elicit silencing in a more limited set of cells, tissues or developmental stages.
Even though pharmacy nurses offer a more limited range of services than CFHCs (for example, they do not offer parenting classes, developmental assessment, mothers' groups, immunization and other programs), they are more numerous and geographically spread in some areas, particularly the BCC, and hence more accessible than their public counterparts [ 22].
In contrast, less severe developmental defects are observed upon targeted disruption of NFκB family members that display more limited tissue expression.
Overexpression of mblA and mblB gave rise to far more limited defects including vein patterning defects (T80-Gal4>UAS-mblA) and abnormal wing position (T80-Gal4>UAS-mblB), thus suggesting a more restricted developmental role.
Our options are more and more limited".
His vocal range is even more limited.
Roman Catholics have even more limited options.
Others might have a more limited effect.
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