Essentially, stronger predictions are also more reliable, i.e. the higher the score, the more likely the mutation impacts function [ 19, 21, 22].
Since neither of these key tumor suppressors impede cell cycle progression in Lmna−/− cells, it is more likely that mutations inactivating A-type lamin function also contribute to tumorigenesis.
During natural selection, transitions are better tolerated because they generate more likely synonymous mutations in protein-coding sequences than transversions.
More likely, these mutations bring about changes in protein protein interactions, changes in localization of diguanylate cyclases in the cell, or alterations in the relative orientation of domains.
Based on his own findings of a loss of ribosomal RNA gene copies in postmitotic tissues of dogs as well as humans during aging, his main conclusion was that deletional mutations are more likely than point mutations to be a main causal factor in aging.
However, many of the mutations described in JEB cases are nonsense mutations near the amino-terminus, which are more likely than the mutation described herein to cause a complete knockout of the gene.
As stop-codon and nonsynonymous mutations are much more likely than synonymous mutations to substantially impair viral fitness, these results are consistent with purifying selection purging deleterious mutations during viral growth.
This is more likely when the mutation is a single nucleotide polymorphism (SNP) and less likely when the mutation is an indel of several bases.
Therefore, it is more likely that the mutation occurred in the bulb type gene, if it was the gene that was affected by the neon-ion beam irradiation.
Professor Rudolph Tanzi of Harvard Medical School further points out that mutations in the human genome do not occur randomly but cluster in "hot spots" that are hundreds of times more likely to undergo mutation.
