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Early tamoxifen treatment labeled a medial cell group (that is, cells nearest to the midline) whereas administration of tamoxifen at later time points labeled progressively more lateral progenitors.
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The DA neuron progenitor zone can be molecularly defined as floorplate cells expressing the cell surface protein Corin and Shh, the latter only expressed at high levels at early stages of development, together with more lateral neuronal progenitors that lack floorplate characteristics and selectively express the signaling protein Wnt1.
In addition, a recent study demonstrated that the characteristic DA neuron transcription factor Lmx1a is important for the appropriate onset of neurogenesis from the midbrain floorplate cells, whereas the related transcription factor Lmx1b is selectively required for the generation of DA neurons from more lateral Wnt1-expressing progenitors [ 11].
Both studies consistently defined a population of more lateral and late Shh-expressing progenitors that preferentially give rise to neurons of the VTA but not the SNc.
He asked for a more lateral motion.
Friends at the university suggested another, more lateral strategy.
It can be a way of thinking and communicating in a more lateral way.
I am more lateral in my movement and more side-on, not giving a full target to hit.
The contrast activated the more lateral ATL regions, extending anteriorly towards the temporal pole (Fig. 4a).
Getting quicker, more lateral speed.
The maps found for the VVN were very similar but slightly more lateral, matching the VVN's more lateral localization.
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