Sentence examples for more large trials from inspiring English sources
More large trials in recent years are improving the evidence base.
Since the 1998 Oxford publication, four more large trials have been reported.
More large trials with high quality are needed to explore the effect of high-intensity statin therapy on clinical outcomes.
More large trials were well conducted than small trials in terms of sequence generating, allocation concealment, blinding, intention to treat, sample size calculation and incomplete follow-up data.
This lack of evidence for improvement in survival with any chemotherapy regimen has created a tabula rasa where no more large randomized trials should be conducted without including a genetic analysis.
It will take one or more large, randomized trials comparing long-term changes in memory and thinking skills among people undergoing bypass surgery, those with heart disease but no surgery, and those without heart disease to tease out how much of this can be attributed to bypass surgery, heart disease, and aging.
The recommendation to start up more large prospective trials must be well thought out before they are launched.
More importantly, large trials examining the basic effect of nutrition delivery with adequate protein delivery (1.2 to 2.0 g/kg/day) on outcome are needed, as these data do not currently exist.
However, results of three more-recent large trials (ACCORD, ADVANCE, and VADT) suggest no significant reduction in CVD outcomes with intensive glycemic control in these populations, who had more advanced diabetes than UKPDS participants.
Considering the serious harm for the missed diagnoses of peritonitis, it is not recommended to use ascitic PCT testing as a stand-alone test, and more larger prospective trials are needed to fully elucidate the potential diagnostic value of ascitic PCT.
Second, most of the studies have a case control design, it has been demonstrated that the case control design could over-estimate the accuracy of a diagnostic test [ 51], therefore more larger prospective trials should be performed to elucidate the diagnostic value of PCT.
