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However, with the availability of genetic data in more and more large study populations, this method remains important for hypothesis generation.
Of the three reviewers who were the least in favour of magnesium, one remarked that he was almost ready to start recommending magnesium after 10 RCTs but most of the trials were small and therefore he preferred to have one more large study.
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But it needs to be confirmed by more large studies.
56 More large studies are needed to clarify these relations.
There is a clear need for more large studies of cancer with high-quality measures of exposure to air pollutants, particularly PM2.5, and the ability to control for important risk factors.
In the next few years, we are cautiously optimistic, but clearly, more large studies are needed to establish its efficacy for treatment of diabetic retinopathy and other vascular complications in diabetic patients.
Clearly, this is just one patient's experience: many more, larger studies would be needed before MDMA is adopted as a treatment.
More recent large study by S. Meeuwsen [ 9] using UK adults has shown that the association is not especially good.
While Ioannidis does have some good suggestions for eliminating bias and relying more on large studies (more data), and reproducibility by separate laboratories to form proper theories, it is hard to see what is new about this.
More large scale studies on young NSCLC patients are warranted.
The relationship between XRCC1 −77T>C and EC susceptibility needs to be clarified by more large size studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com