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In contrast, the process of gene identification is far more laborious in forward genetic screens since a causative (usually point) mutation must be identified amongst the entire genome.
Histological analysis of a biopsy sample, more laborious in preparation and study as compared with that of a cytological smear, is also not absolutely efficient owing to a substantial rate of interobserver discrepancies among expert pathologists examining the same material [ 4].
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The in vivo approach, while more laborious, resulted in more significant outcomes, clearly showing that sperm with functional mitochondria are more likely to undergo chromatin decondensation and thus participate in early development.
The variability of the vessel density in tumors derived from the same cell line makes quantitative assessments more laborious than in genetically homogenous, inbred, mice; but this probably better reflects the intra- and inter-individual heterogeneity of human tumors.
It's a market scenario that creates a barrier to entry for competition, because the process of obtaining listings is more laborious than in the US.
They aimed to observe as many first ANC visits as possible because they were more laborious, differed in important aspects from later visits, and were less frequent.
Although these screens are more laborious than screens in Drosophila cell lines, or whole-genome RNAi screens in worms (i.e. Caenorhabditis elegans screens can be done on plates), screens using intact flies can be accomplished either by classic mutagenesis or by screening high quality collections of stable UAS-RNAi stocks.
In some cases, controlled image-capturing conditions can make the fieldwork more laborious which incurs in significant costs for monitoring campaigns considering large areas.
Trilogy is not an ideal title, suggesting a more laborious endeavour than in practice it is.
In addition, they are more laborious to measure, both in terms of needed equipment and in testing time.
Among the attractions is NJ Transit's Midtown Direct train service: commuters leaving Millburn end up at Pennsylvania Station in Manhattan, avoiding the more laborious route that terminates in Hoboken, where Manhattan-bound riders have to transfer to PATH trains.
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