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Clusters 6, 7, and 13 contained the highest proportion of genes with maximum expression in meristems, in agreement with the observation that genes in these clusters are strongly expressed during the earliest floral stages, but are repressed towards more intermediate stages when meristematic activity in flowers ceases.
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It is well-documented that fibril formation occurs via one or more oligomeric intermediate stages [36] [40] and it appears that an intermediate oligomeric species, rather than the mature fibril, is the mediator of cyto- and neurotoxicity [41] [43].
At the moment it is clear that viscosupplementation is more efficacious in the initial and intermediate stages of OA more than at an advanced stages and that this therapy is exceptionally safe compared with other OA treatments.
The scale of these rearrangements is impressive given that these changes have happened within a family of gastropods, and suggests that further sampling of the Vermetidae should uncover more changes and perhaps intermediate stages that may reveal the dynamics underlying the gene rearrangements shown here.
Meléndez-Hevia et al. (1996); Miller (2004); Finnigan et al. (2012), and others are showing that various examples of 'irreducible complexity' - structures which 'could not have evolved' by a succession of intermediate stages, each more advantageous than the last - are in fact reducible.
Moreover stem cells provide tissue engineers the freedom to choose cells at a more defined or intermediate stage of differentiation.
Transitions and intermediate stages may be more concretely envisioned or documented.
These mechanisms are more active in the initial and intermediate stages of PD, declining in the final stages [ 108, 109].
On this basis, all mRNA in the process of degradation would be part of a common pool, and thus, for two mRNAs with the same overall level of accumulation but different half-lives, degradation intermediates of the shorter-lived mRNA would be expected to be more common, since this transcript will have a higher rate of synthesis and thus more intermediates at each stage of degradation.
Any power loss occurring locally in intermediate stages of a ST results in more available energy in the downstream stages.
NiW/Al2O3 catalysts are more difficult to sulfide than their Mo-based counterparts and, hence, intermediate stages of sulfidation can be studied as separate phases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com