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The atlases used could be divided into single-subject topological and population-based probabilistic atlases [75], single-subject atlases revealing more interindividual differences and population-based probabilistic atlases revealing more intergroup differences.
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More fundamentally, interindividual differences are likely so that having an identical MAP target for all patients is probably naïve.
This limitation constrains conclusions based on HOMA-IR in our previous study [ 43] and also the present one, all the more because interindividual differences in ADMA could influence NO bioavailability [ 87].
Future use of EEG, perhaps in combination with MEG, might be more sensitive to interindividual differences in radial and deep sources of neural activity (Hämäläinen et al., 1993).
However, as the majority of toxicities are thought to be due to the slow glucuronidation of SN-38 49, 49, it was decided that the higher DNA damage levels induced using this metabolite would be more informative and more likely to detect interindividual differences than the lower levels detected following irinotecan exposure.
The genotype responsible for the more than 60-fold interindividual differences in human hepatic CYP1A2 constitutive expression is not known [47].
For reliability, we found that interindividual differences were more dependent on the placement of the device than other characteristics, such as weight or height, which did not contribute to excessive variability (data not shown).
Wide interindividual differences in metabolism result in different DNA adduct levels.
These data were obtained in tissues from different individuals and possible interindividual differences cannot be excluded.
The proposed measure of interindividual differences in metabolism and excretion (%MEHP) was more stable over time within a pregnant woman than the corresponding DEHP metabolites by approximately 2-fold.
One explanation for our findings may be a far more complex regulation of CDA gene transcription, leading to substantial interindividual differences in quantities of CDA enzyme, unrelated to the 79A > C polymorphism.
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