Sentence examples for more interacting partners from inspiring English sources

The observation that proteins with more interacting partners are subject to stronger levels of selective constraint suggests that direct protein protein interactions impose constraints on protein sequence evolution.

Furthermore, more interacting partners and downstream targets of BCAS2 need to be identified to decipher the consequences of its amplification in breast cancer.

When candidate genes have more interacting partners in a network and are closer to other known disease genes, RW may perform better than the other methods.

Yeast proteins that have a large number of interacting partners were found to have evolved slower, on average, than those with fewer interacting partners, and this was presumed to be due to the fact that proteins with more interacting partners have a greater fraction of residues directly involved in function.

However, it was previously noted that self-interacting proteins tend to have more interacting partners (higher connectivity) than non-self-interacting genes [ 9] and we confirm this for our dataset.

We applied simple logistic regression [ 28, 29] to measure the proportion of genes encoding self-interacting proteins over all genes with a particular number of interacting partners (degree) k, and in accordance with Ispolatov and colleagues [ 9] we found that self-interacting genes tend to have more interacting partners in general (not shown).

Finally, self-interacting WGD genes tend to have more interaction partners in general in the PIN, which can be explained by their overall greater age.

In our study, we focus on proteins with more than three interacting partners in the PPI network, since poorly connected proteins are more likely to reside in incomplete parts of PPI networks [ 17, 18].

However, in the clustering process and in subsequent analyses of the clusters, we consider only nodes with more than three interacting partners in the network; consequently, we consider only edges with both end nodes having degree of more than three.

The finding that there were more Hsp60-interacting partners with the cell wall extracts with increasing temperature suggests that the trafficking activity of this protein and localization of several proteins to this organelle is augmented at high temperature stress condition.

In their recent study on protein-protein interactions, Ekman and co-workers noted that hub proteins (those with a large number of interacting partners) are more often multi-domain proteins and contain more disordered regions compared to non-hubs.