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Here, we assume that whenever two given proteins possess one or more interacting domains between them, those proteins will interact.
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In light of this it is quite possible more RNA-interacting domains will be identified in the coming years as new structural studies on Mediator are published.
SMRT contains two interacting domains that mediate interactions with nuclear receptors.
Furthermore, it has been shown recently that such co-evolution is more evident if we focus our attention on interacting domains that are responsible for PPIs (Itzhaki et al., 2006; Jothi et al., 2006; Schuster-Böckler and Bateman, 2007).
For proteins with interacting domains, some lectins and PME inhibitors are more abundant at 5 days.
For instance, WD40 domains were found to take part in more interaction pairs than any other domain in yeast, and being as the one of the most interacting domains in human interactome datasets [ 7- 10].
Indirect interactions potentially emerge in any community of three or more interacting species [1], [2].
With the discovery of more leucine zipper sequences and growing insights into the mechanism of helix formation, several groups have pursued library approaches to engineer interacting domains that might best induce heterodimer assembly [15], [16].
All orthologs have 12 predicted transmembrane helices (Viklund and Elofsson [2004]) separating two interacting domains and the substrate binding domain (Yan [2013]) (Figure 8).
No more interacting.
A full list of known interactors and their interacting domains based on remotely conserved domains can be found in Supplemental Table S6.
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