Sentence examples for more intensive mutation from inspiring English sources

Nevertheless, these studies point out the need for more intensive mutation screening than coding region and splice junction sequencing.

Haplotyping has also been useful in redirecting mutation analysis, for example if the majority of affected individuals in the family shared a BRCA1 or BRCA2 haplotype but the screened individual(s) did not, and to prioritize families for more intensive mutation analysis such as full sequencing or genomic rearrangement analysis.

Thus, the introduced mutation promoted more intensive viral uptake in the mouse respiratory tract.

In healthy mutation carriers, the presence of one of these mutations may justify more intensive surveillance, chemopreventive approaches [ 84, 85], and/or prophylactic surgeries [ 86] that would not otherwise be justified by family history alone.

These important findings support the primary importance of mtDNA mutations in the changes observed in cardiac morphology, and may support more intensive cardiac evaluation of patients with higher mutation loads and/or NMDAS scores.

Women who carry BRCA1/2 mutations often opt for more intensive screening at an early age for ovarian cancer, including pelvic examination, transvaginal ultrasound, and serial monitoring of tumor marker CA125.

This finding could have important clinical implications as men with deleterious germline mutations in these genes should be considered for more intensive screening and treatment.

Because of the high risks, it is important to identify BRCA1/2 mutation carriers and offer them options to manage their risks; that is, more intensive screening or risk-reducing surgery (prophylactic mastectomy and/or salpingo-oophorectomy).

Women who discover they carry harmful BRCA mutations can opt for preventative surgery to remove their breasts, or have more intensive screening for tumours.

For example, women with BRCA1 mutations may be identified through genetic testing with a view to offer more intensive preventive options, including mammographic screening, chemotherapy or prophylactic surgery.

Given that there is a 12% population lifetime risk, deleterious common mutations contribute a 24%36%% lifetime risk, which may be high enough to instigate earlier and more intensive screening for common genetic forms of the disease.