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Pathological grading showed that PBS injected eyes (EAU grade, 3.08±0.66) and AAV2.GFP treated eyes (EAU grade, 3.2±0.76) had significantly more intensive inflammation as compared to the AAV2.hIFN-α treated eyes (1.33±0.6 for low dose, 1.4±0.58 for high dose) (P<0.0001) (Figure 5I).
Since CRP is a major positive acute phase reactant [ 19], higher CRP levels are likely to reflect more intensive inflammation, which in turn suggests that patients with indeterminate QFT results have higher levels of inflammation than those with determinate QFT results.
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The lack of significant associations between SJC or ESR and PPT suggests that ongoing inflammation was not the predominant drive for pain sensitivity in these patients, but interventional studies would be required to determine whether more intensive suppression of inflammation in early arthritis could reduce the contribution of augmented processing to pain even after inflammation is controlled.
Higher CR-P values in patients with ISV (Table 3) point to more intensive necrosis and inflammation than in indviduals with ATD-induced diseases.
Significant cell infiltration and proliferating epithelium (Fig. 1b) appeared to be more intensive in the chronic inflammation.
Therefore, we propose that CCL2 serves a dual role as a potential biomarker of fitness and inflammation in obese children; CCL2 may aid the definition of fitness levels and demarcate a group of children who have more inflammation despite having similar metabolic profiles to other obese children but may require more intensive interventions to treat obesity-related inflammation.
The effect of treating people with more intensive therapies to ensure that their joint inflammation is minimised, will be assessed.
IDEA is the first adequately powered, long-term trial to examine whether more intensive weight loss, with or without exercise, will reduce inflammation and knee joint loads sufficient to alter disease progression.
An explanatory hypothesis could be that the perception of persisting local inflammation in the operated body part at 30 days is more intensive in preoperative healthier patients.
While drug treatment completely reversed lung inflammation associated with secondary lesions relatively quickly, the resolution of the primary granulomas required more intensive treatment regimens [45], [53].
"It's much more intensive.
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