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Of note, only 22% of CRRT patients received a more intensive dose.
Clearly, the delivery of cytotoxins, drugs, and small molecules targeting genes or pathways to the primary tumour with minimal systemic toxicity will allow the testing of new combinatorial approaches and more intensive dose schedules.
Similarly, it should be possible to investigate more intensive dose therapy with DAC in patients with leukemia who have a good performance status, since the pharmacology would predict reversible toxicity with DAC as well [ 18].
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Even in the era of widespread taxane use, more intensive dose-dense adjuvant regimens, and targeted therapy with Herceptin in HER2-positive patients, longer follow-up reporting of older adjuvant breast cancer trials remains vital in order to confirm the activity of these regimens through time.
Recent studies have suggested that more intensive dosing of both continuous [ 9, 10] and intermittent [ 11] RRT are associated with reductions in mortality; however, results have not been consistent across all studies [ 12] and these findings have not been widely applied in clinical practice [ 13].
Only 22% of CRRT patients and 64% of IRRT patients received a more-intensive dose.
We also observed that CRRT patients receiving more-intensive dose had significantly lower body weights.
Only 75 patients (22%) received more-intensive dose (≥ 35 ml/kg/hour), while 262 (78%) received less-intensive CRRT.
In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose escalation using a hypofractionated regimen with reduced dose to the normal liver, usually below the threshold dose above which severe RILD is observed.
In recent years, the introduction of stereotactic ablative radiotherapy (SABR) has offered even more intensive tumor dose escalation in a few fractions with reduced dose to the adjacent normal liver.
The more intensive Doc dose, 150 mg m−2, is optimally supported by the slightly less cost-effective G-CSF 300 μg, Q1D × 4, 5 days post-Doc.
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