Model is validated by comparing its predictions with those of the computationally more intensive multi-electrode cell model.
The inner hair cells, pillar cells, and Deiters' cells displayed more intensive staining for TLR4, but the outer hair cells did not (Fig. 2g).
We anticipate these data, along with more intensive investigations of primary cell lines, will yield important information and significantly impact the search for new molecular targets for therapeutics.
The goal for this is to identify patients for appropriate immediate salvage therapy (e.g., more intensive chemotherapy or stem cell transplant).
However, TRAIL- γ was found to produce a more intensive fluorescence of the cell surface and nuclear membrane when compared to the other splice variants.
Then, if the proof of concept is established, a more systematic use of intensive cell cycle-specific chemotherapy, together with protection of other lineages through temporary mitotic blockade might be a treatment applicable for most cancers.
In our experience, patients with advanced stage of disease (i.e. subdiaphragmatic organ involvement) had a lower achievement of CR and a very poor outcome, suggesting that in these patients more intensive approaches, including stem cell transplantation, should be early considered.
In general, s100 staining was more intensive in the plasmatic cells.
Expressions of GRP78 were more intensive in infiltrating plasma cells in RA synovium relative to those in OA synovium (P < 0.001) and in synovium with follicular synovitis relative to that with diffuse synovitis (P < 0.001).
Cell-in-cell formation affects both effector cells and their host cells in multiple aspects, while cell-in-cell death is under more intensive investigation.
