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Similar considerations about the methodological variability across studies apply to these more intensive assessment phases.
The detection of an increased frequency of events would typically trigger more intensive assessment, including more diagnostic testing than would ordinarily be indicated.
For example, if the patient already exhibited signs of poor nutrition (such as obesity), more intensive assessment of diet and physical activity would usually be undertaken.
Most nurses did not feel sufficiently confident about their assessment skills when they started with the intervention, and indicated that they would have preferred a more intensive assessment training schedule.
A more intensive assessment of pesticides in food comes from the "duplicate plate" method, wherein exact duplicates of a person's daily meals and snacks are prepared concurrently with their consumption and then measured for pesticide residue levels (Clayton et al. 2003).
Studies where understanding mechanism of effect is a major focus clearly require more direct assessments of intervention fidelity, whereas those studies whose main question is "does the intervention work under usual conditions?" may limit their generalisability by more intensive assessment of study processes.
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Typically, this comprised a preliminary risk assessment followed by more intensive assessments conducted over multiple sessions (among those likely to be at increased risk, or with complex or unclear presentations), together with various neuropsychological and self-report measures [ 41].
The resolution of these issues is one of cost benefit: are the costs of a more intensive site assessment offset by better selection of the area to be planted?
More intensive intraoperative assessment with serial sections and immunohistochemistry has been described, but this is time consuming and labour intensive.
For more intensive neurobiological assessments (e.g., blood draws during stress protocol) numerous safety measures have been put in place (e.g., exclusion of children with acute and severe psychopathology; positive feedback to children at the end of the task; children are accompanied by a caregiver to and from the lab).
In addition, a sub-sample of 7,519 patients passed a more intensive standardized laboratory assessment and was followed up after one year in 2004, and after 5 years in 2007/8.
More suggestions(15)
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