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This was not surprising, given the expectation of more intense purifying selection on coding sequences.
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By using the high-quality data provided by the Drosophila Population Genomics Project, we have found that evolutionary conserved regions (i.e., genes with lower K A and longer introns) show clear evidence of more intense on-going purifying selection than less conserved genomic regions, which can be detected by analysing patterns of genetic variation both within and between subpopulations.
Also, exonization usually occurs in untranslated regions (UTRs) [3] or within duplicated genes [34], further supporting the idea that purifying selections are more intense on exonization events that occur within CDSs.
This in turn implies that the more rapid protein sequence evolution of these genes mainly reflects weaker purifying selection, not more intense positive selection, consistent with the fact that the α values in table 3 are not exceptionally large in comparison to those from other studies of Drosophila species (Sella et al. 2009; Campos et al. 2014).
Additionally, the PA63 bands purified by anti-PA were more intense (lanes 5 8).
However, it clearly appears that the hybridization signal of low M.W. transcripts present in the RNA purified with our procedure is much more intense than that seen in the homologous C sample.
This raises the possibility that for proteins under stronger purifying selection the clustering of amino acid differences in a pairwise comparison is more intense.
It's more intense".
More intense?" She coughed.
Their defense is more intense.
Mr. Gimenez grew more intense.
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