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The discovery of higher-level mechanisms that adjust how much protein a gene makes is a persuasive argument for a more integrated understanding of biology.
First, a more integrated understanding of the complex pathophysiology and progression of AD is needed to identify the appropriate pathways and the disease stage to target.
We discuss future directions in these areas with potential inputs from NGS technologies and propose avenues for developing a more integrated understanding of genetic diversity and its impacts on genome function.
Recent developments in flow cytometry and next-generation sequencing technologies have led to major discoveries over the past few years, providing a more integrated understanding of the developing human immune system in the context of its microbial environment.
There is a pressing need to integrate research platforms in genomics, epistatic models, proteomics, metabolomics, neuroimaging technology and translational studies in order to allow a more integrated understanding of glutamate and GABAergic signalling processes and aberrations in SZ and BD as well as their relationships with clinical presentations and treatment progress over time.
In addition to providing new insight into the variety of congenital heart disease phenotypes that can be produced from second heart field defects in humans, our observations also may provide the basis for a more integrated understanding of the molecular basis of human congenital heart disease.
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Moreover, there are supra-national organizations and NGOs such as the New Economics Foundation in the UK that have long proposed new indicators of economic progress grounded in the belief that we need a more holistic, integrated understanding of the economy instead of one that is purely based on financial terms.
By doing so, they point the way to a more holistic, integrated understanding of migration systems which takes objects and subjects; structures and agents; and goods, ideas, and behaviors as intimately related and co-produced within the transnational social fields in which they are embedded.
This review article begins with an introduction to PD neurobiology as a foundation for interpreting neuroimaging findings that may further lead to more integrated and comprehensive understanding of PD.
Mike Fogarty, the marine biologist and head of the agency's ecosystem assessment program for the region, defends the government's fish stock analyses -- though he adds that more integrated approaches to understanding and modeling the ocean biosphere, including the ability to identify and fold in crucial new inputs arising from climate change, remain a work in progress.
Element-based approaches cleave the ecosystem into known static bits and pieces[ 12, 13], while deeper analyses of natural variation require a more integrated and dynamic understanding of the processes affecting the ecosystem as a whole[ 14].
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