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Our experiments show that a single nuclear traversal by a Fe-ion produced more initial chromatin breakage than one Cr-ion, but after 24 h of repair the number of excess fragments/cell was similar for both ion species.
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To our knowledge, ours is the first report implicating the 19S proteasomal ATPases in regulating the initial chromatin remodeling events at cytokine-inducible promoters that releases surrounding chromatin from a more condensed, repressive state.
Finally, after DNA repair, the initial chromatin structure has to be reestablished.
Thus, the initial chromatin reorganization event regulated by 19S ATPases remains to be determined.
Aligned like-regions could make more Van der Waals chromatin fiber-chromatin fiber contacts between homologues, and could therefore lead to significantly stronger associations than those between unlike-regions.
Initial studies pointed to a model that the SIR complex silences transcription by promoting the formation of a more protected chromatin structure that is not accessible to the transcription machinery.
Quiescent T cells possess a condensed chromatin, whereas proliferating T cells have a more open chromatin configuration.
Chromatin of children transformed into a hyper-activated and more accessible chromatin state in response to maternal smoking, especially in regulatory regions of the genome, so called enhancer regions.
More recently, chromatin emerged as a novel node in the network of splicing regulatory interactions.
It can be concluded that CBHA can improve the transcription activity of these genes, which should be related to the more "open" chromatin configuration.
These HDAC inhibitors (HDACi) work to prevent histone deacetylation, facilitating a more open chromatin configuration and leading to increased gene transcription.
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