Exact(3)
In mouse data also, cell lineage-specific or inducible expression of genes are associated with more informative annotation, reflecting the priorities of studies on gene function [ 23].
As with the 'unknown' class, for which any improvement is through replacement of the 'unknown' annotation with a more informative annotation, we place a high priority on curation of those gene sets where addition of a missing annotation is required.
In this study, we extended this analysis to include additional sources of computational predictions, in order to determine whether this would increase our coverage across the genome and help enrich for those genes which could be updated from an 'unknown' to a more informative annotation.
Similar(56)
In this sense, it is not exactly correct to assert that BLAST and naïve are (almost) the best performing tools because many tools participating to CAFA, whenever possible, tried to provide more informative annotations in place of the less informative "protein binding".
This formulation naturally downweights proteins with less informative annotations compared with proteins with rare, and therefore more informative (surprising), annotations.
This procedure was employed because the SwissProt database provides more informative functional annotations, but the NR database is larger and has the possibility to annotate sequences not available in SwissProt.
A more informative analysis of functional annotation was achieved by studying the enrichment of differentially expressed genes in a particular pathway.
We found that distance to the transcription start site, evolutionary constraint, and epigenetic annotation were considerably more informative for predicting the impact of rare variants than for predicting the impact of common variants.
It would be more informative to actually state in the annotation a score for each feature.
Compared to the functional similarity measurements used by other studies [ 27, 28, 30], the functional distance method used here considers the overall annotation pattern and is more informative.
With that in mind annotators should use more informative gene names as a preference, choosing alternative gene names over the original y-gene annotation.
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