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Infected and activated cells also produce chemokines such as monocyte chemotactic protein-1 (MCP-1), attracting more inflammatory monocytes and macrophages [37] [39].
Infected and activated cells also produce chemokines such as monocyte chemotactic protein-1 (MCP-1), thereby attracting more inflammatory monocytes and macrophage [23], [24].
Four hours after infection, 6-OHDA-treated mice recruited more inflammatory monocytes to the infected peritoneum.
Similar(57)
Resident monocytes, alveolar macrophages, granulocytes (Supporting Information Fig 4) and more importantly, inflammatory monocytes were detected in similar amounts in CCR2−/− and WT mice (Fig 3B and Supporting Information Fig 4).
By FACS, IL-10R blockade resulted in a sharp decrease in the percentage and number of inflammatory monocytes in the lungs by more than 50% compared to control mice (Fig 6A and Supporting Information Fig 7B).
We found both CD14+ and CD16+ monocytes significantly reduced after storage (the latter, thought to represent inflammatory monocytes [9] in humans were more markedly affected).
More careful analysis of cellular subtypes showed an increased number of granulocytes and inflammatory monocytes identified as SSChigh CD11b+ Gr‐1+ cells in circulation in G3 mTerc−/− (SSC indicates side scatter in flow cytometry; Fig. 5K) indicating increased inflammation.
10 12 More recently, neutrophils that express matrix metalloproteinase 9 (MMP-9), 13 15 as well as inflammatory monocytes, have been implicated in the regulation of angiogenesis in a variety of experimental models of disease.
In addition, monocytes regulate the inflammatory process by secreting cytokines and growth factors, thereby recruiting more inflammatory cells as well as by antigen processing/presentation and lymphocyte activation.
That might be a bit more inflammatory.
The number of CCR2+ inflammatory monocytes was quantitatively compared (E) (n = 6).
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