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A more recently published study describes TKTL1 to be indispensable for the function of the p53-dependent effector Tp53-induced glycolysis and apoptosis regulator (TIGAR) on hypoxia-induced cell death.
These findings suggest that RXRα is indispensable for the function of PPARα, FXR, LXR and PXR in the mouse liver.
In particular, the expression of p66Shc is indispensable for the function of the p53 isoform (p44/p53) to induce of G2/M cell cycle arrest, after oxidative stress.
It is therefore very likely that at least some of the conserved residues are indispensable for the function of the LytR-CpsA-Psr domain in these proteins.
However, Rammelsberg et. al. reported that none of the residues involved are completely indispensable for the functioning of the proton pump [ 78].
In TPPI, the glycosylation of N residues has been indispensable for the biological function.
The extracellular matrix (ECM) is a highly organized multimolecular structure that is indispensable for the normal functioning of organ systems.
And the more indispensable you become, the more valuable you become for hiring managers looking to hire top talent.
Ago proteins are the key component of the siRNA and miRNA pathway and are indispensable binding proteins for the function of many other small RNAs.
Ago proteins are key components of the siRNA and miRNA pathway and are indispensable binding proteins for the function of many other small RNAs.
Thus, an N-BAR domain appears to be indispensable for the in vivo function of endophilin.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com