Thus, the conclusions drawn from this study should be treated with caution, and more independent replications with more SNPs genotyped for each sample, ideally in larger and equal samples, are needed.
The association has since been tested in other samples, and although the results are conflicting [ 23- 26], the occurrence of more than one independent replication [ 24, 26] of an association that originated from an unbiased GWAS is encouraging.
Furthermore, we emphasize the need for more sensitivity testing and for independent replication of empirical results within the finance profession.
It awaits independent replication in more patients, yet intriguingly suggests that repressing the pool of latent HIV DNA in microglial cells is potentially feasible.
Independent replication is needed before more firm conclusions can be drawn.
Our results provide this independent replication, although with a more modest effect (OR = 0.83 in our study versus 0.70 in Kozyrev and colleagues [ 5]).
For publication of novel rare variant associations, independent replication is equally important, but can be more challenging than for SNPs identified by GWASs.
In regard to IL12A rs77583790, our results do not provide an independent replication; however, the meta-analysis shows a more significant P value when the French population is added, suggesting that this locus is further confirmed by our data.
However, more, large scaled MRI data sets are becoming available allowing for independent replication testing.
Nonetheless, this method is still more likely to yield errors over the preferred method of complete, independent replication of both steps by at least two reviewers.
