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Future studies using more in depth functional studies and other organisms will be needed to support this hypothesis.
To further investigate these subsets, we focus on blood cells and brain tissues, which illustrate the clearest separation between their tissue-selective and conserved genes in their TSS distribution, and subject them to more in depth functional analysis in next subsections.
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We have combined our previous genome-wide analyses [11] with more in-depth functional studies, identifying the EBP1 gene as a bona fide E2F target.
This pre-selection is an enabling discovery for further, more in-depth functional work to unravel cyst nematode parasitism.
Polymorphisms in the CAST gene have also been associated with meat tenderness in pigs, though more in-depth functional assays have yet to be made beyond this association.
Because Brassica oleracea and Arabidopsis thaliana are both members of the family Brassicaceae, protein identification was facilitated by the availability of the well-annotated Arabidopsis genome allowing a more in-depth functional analysis.
Still, more in-depth functional studies are needed to provide an answer as to whether histone H3 acetylation levels or other epigenetic markings are crucial in the PML RAR α-induced transformation process.
The pending availability of further genomes (Robinson et al. 2011) will not only further boost the powers of comparative genomics but also call for more in-depth functional and molecular investigations on selected genes to resolve issues of mechanisms and implications of gene loss and gain.
Almost none of the available bioinformatics tools for functional annotation of metagenomic sequences are capable of handling such errors; although several specialized tools for frameshift detection are currently available [ 89 93] in the public domain and should be used for more in-depth functional analysis.
A more in-depth study of functional hybrid nanomaterials would provide new opportunities for high-performance wearable devices.
More in-depth sampling and functional analyses of these genes in the future may reveal more molecular details concerning the adaptation of the Tibetan population to high-altitudes.
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