On the other hand, p16INK4a (p16) is slightly induced in MIN from transgenic animal and lost in carcinomas (Figure 3) suggesting that Rb pathway may be a more important senescent checkpoint than p53 in AKT-derived tumors.
Both CHK1 and CHK2 can activate p53 upon DNA damage (Shieh et al., 2000) and are important for cell cycle checkpoints, however, while CHK1 is crucial for intra-S and G2/S transition, CHK2 is more important for G1/S checkpoint (Liu et al., 2000; Takai et al., 2000, 2002; Hirao et al., 2002).
These observations suggest that at low levels of telomere uncapping, Dot1 has a more important function in Rad9-dependent checkpoint activation that it does at higher levels of uncapping, when presumably alternative mechanisms ensure that Rad9 is activated.
We show that in human cells its contribution to the spindle checkpoint response is more important that that of the hNDC80 complex.
In this context, checkpoint regulatory activities of ARTEMIS may be more important than the DSB repair function with regard to sarcoma suppression [ 12- 14].
We conclude that cdc13-1 exo1Δ pif1Δ mutants generate limited, transient ssDNA that is insufficient to stimulate checkpoint activation and that Exo1 is much more important than Pif1 for ssDNA generation in the TG repeats following telomere uncapping.
More important, security forces are continuously tightening an extensive ring of checkpoints around the potential borders of an Alawite canton.
This is in contrast to the relative importance of the two proteins in signalling checkpoint-dependent cell-cycle arrest, in which Mec1 has a much more important function (Usui et al, 2001; Mantiero et al, 2007).
We will also see more important news on the potential of anti-PD-1/PD-L1s in combination with other approaches, including other immunotherapies (e.g. checkpoint inhibitors), radiotherapy, chemotherapy and targeted agents.
More important, he said, were the Israeli restrictions faced by average Palestinians, which he described as "the siege, the reoccupation of liberated Palestinian areas, these checkpoints that you see for yourself".
